Vaccination of pigs against Salmonella typhimurium
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Research partners: University of Edinburgh
Sponsors: BPEX
Project duration: 2007 – 2010
A key intervention which could reduce the number of food poisoning incidences caused by S. Typhimurium is vaccination and it is hoped that a novel S. Typhimurium vaccine can be produced for use in the pig industry where a vaccinated animal can be distinguished from an infected animal in the abattoir by a simple test.
The overall objective of this project is to identify the roles of different Salmonella Typhimurium binding factors in colonisation of the porcine intestine and to modify S. Typhimurium vaccine strain (VacT) for differentiation between vaccinated and infected animals.
Current work suggests a role for one of the bacterial surface proteins in S. Typhimurium colonisation of porcine gut. Work is in progress to determine the porcine receptor for this bacterial factor and to immunocharacterise this protein, which could be part of a future multivalent vaccine to control S. Typhimurium in pigs.
Page last updated:
11 April 2011